JOURNAL

The Use of nPEP to Prevent HIV Transmission
Health & Homeostasis, Positive Sexuality Victoria Froud, MA Health & Homeostasis, Positive Sexuality Victoria Froud, MA

The Use of nPEP to Prevent HIV Transmission

Everybody occasionally partakes in behavior that is potentially dangerous, whether this is intentional, such as casual unprotected sex, or unintentional, such as a workplace injury. The consequences of those actions can be scary, but perhaps the scariest of all consequences is transmitting a life-affecting virus such as HIV – and both of the previous examples could have this result. Of course, there are ways in which you can help protect yourself – avoiding risky situations where possible and following safety advice such as using condoms are a good start – but it’s impossible to avoid every potentially dangerous situation in life. Sometimes, risk of exposure to HIV is going to happen. So is there any way that transmission of HIV can be prevented after exposure? Perhaps surprisingly, the answer is yes. PEP, or post-exposure prophylaxis, is a treatment given to those who have been exposed to a high risk of HIV transmission and it’s used as a preventative medication in order to stop the virus in its tracks.

What is PEP?

PEP is essentially an antiretroviral (ARV) therapy made up of a combination of one to three ARV drugs and is actually the same therapy used to treat HIV once transmitted[1]. Originally only given to occupational exposures, such as needlestick injuries in health care workers, the US Department of Health and Human Services (HHS) offered guidelines in 2005 for the use of PEP in non-occupational (nPEP) cases such as exposure through sexual activity or drug use as well[2]. The treatment is given to those who test negatively for HIV and have been exposed to a high risk in a single case (ongoing exposure, such as a person with an HIV positive partner, is not normally treated with PEP, but with an alternative drug, PrEP – pre-exposure prophylaxis). In contrast to occupational PEP, nPEP is generally coupled with risk-reduction counselling and education in order to help patients learn from their damaging behavior. It is also only administered if treatment is sought within 72 hours of the exposure – any longer than that, and the treatment simply isn’t effective and therefore isn’t prescribed[3].

 

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Cheat Days: Heaven-Sent or Wishful Thinking?
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

Cheat Days: Heaven-Sent or Wishful Thinking?

Dieting is hard. It’s as simple as that. You are depriving yourself of the things you love and if you are new to dieting, there is a chance that you could be suffering withdrawals from sugar and processed foods too. If only there was a way to maintain a healthy diet and eat the things you love. Well perhaps there is. Many now argue that having a ‘cheat’ meal or even a whole day can actually help rather than hinder your weight loss goals. What this means in real terms is that whilst you continue your dieting struggles, you can still indulge in your favourite things on a regular basis, albeit once a week rather than once a day! Some go on to argue that not only is a cheat day enjoyable, but it’s also vitally important to the success of your regimen. Carolyn O’Neil, co-author of The Dish on Eating Healthy and Being Fabulous, explains that “sensible splurging is really the key to being able to achieve a healthy lifestyle.”[1] Sounds good right? But is it too good? Can a cheat day really be good for your diet or is it all just wishful thinking?

Motivational Donuts

Perhaps one of the most obvious benefits to a cheat day whilst dieting is a psychological one. It can be tough when you are stuck eating things that perhaps you don’t enjoy whilst seeing everyone else tuck into your favourite foods. The idea of never getting a taste of that delicious treat again can be devastating – and could potentially de-rail even the most determined dieter. So the possibility of a motivational donut or other treat at the end of the week could really help keep you on track. Joe Vennare, creator of Hybrid Athlete, says just that. “It’s a reward for hard work in the gym and adherence in the kitchen,” he claims[2]. Jillian Guinta, professor of Health and Physical Education at Seton Hall University agrees with him, stating that “oftentimes, it may take several weeks to see the scale budge, so knowing that a cheat day is coming up can help keep up motivation.”[3]

 

 

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Men’s Health: Friendship is as Important as Exercise
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

Men’s Health: Friendship is as Important as Exercise

It’s nice to have friends. It makes you feel good about yourself, you have someone to do stuff with, and you have a source of ongoing support. Friends are great, there’s no doubt about that, but is it more than that? Recent research says yes. In fact, findings show that friendship between men can actually improve their physiological health as well as their mental well-being. For one thing, a good ‘bromance’ can help to reduce stress – and stress is a known factor in many physiological issues, including cardiovascular disease and heart attacks. But what exactly is it about friendship that is so great? And are men able to create strong enough bonds for friendship to show its true benefits?

 

Rat Friends

A study recently published in Neuropsychopharmacology journal claims that men who are close to other men have higher levels of oxytocin in their brains – a chemical often referred to as ‘the cuddle hormone’. It’s this hormone that makes people better at handling stress and it’s this, research claims, that helps to improve men’s physical health[1].

The study, conducted by Elizabeth Kirby of Stanford University, put male rats into mildly stressful situations – namely that of being stuck in a confined space for around three hours. Those rats who had previously had ‘friends’ (i.e. those which had been in cages together for one week previously in order for them to bond) showed higher levels of oxytocin, the anti-stress hormone, than those rats without friends[2]. What’s more, the study showed that being placed under stressful situations made the rats more likely to be social and co-operative, as those who returned to their ‘friends’ touched each other more, huddled together more, and generally helped each other overcome their difficult situations[3].

 

 

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Do Big Moms Make Big Babies?
Health & Homeostasis, Women's Health Victoria Froud, MA Health & Homeostasis, Women's Health Victoria Froud, MA

Do Big Moms Make Big Babies?

There are a lot of stories and old wives’ tales surrounding pregnancy and birth, and each and every possible factor of having a baby is subject of discussion. The potential size of your baby is no different, and whether or not you’ll have a large baby is a question on many people’s lips. Thanks to recent research though, that question can now be answered – at least for some people. Studies show that mothers who are overweight or obese during pregnancy are much more likely to have big babies than smaller mothers.

A recent co-operative review study between universities in the UK looked at research involving more than 30,000 women of European ancestry and their babies. The studies examined the mother’s body mass index (BMI), blood sugar levels, and blood pressure as well as the weight of the resulting babies. The results, published in the Journal of American Medical Association, demonstrated that not only will larger moms have larger babies, but moms with high blood sugar levels (whether overweight or not) will also have bigger babies. Conversely, moms with high blood pressure will have smaller babies[1].

Big Babies

The size of the average baby is around 6-7 pounds[2], but the amount of babies being born at 9.9 pounds or more has increased over the last ten years[3]. These are known as LGA babies, or ‘large for gestational age’. The American Journal of Obstetrics and Gynecology suggests that overweight moms are twice as likely to have an LGA baby and obese moms are three times as likely. What’s more, a study by the Kaiser Permanente Center for Health Research shows that women who gain 40 pounds or more actually during the pregnancy are also twice as likely to have LGA babies[4], even if they started out with a healthy BMI. So the statistics show that this increase in baby size is there, but the questions we’re left with are why are babies getting bigger? And why does it matter?

Bigger Babies

The fact that babies are getting bigger is not only due to the size of the mother, of course. One of the most obvious reasons that babies are getting bigger is that we are getting healthier in terms of pregnancy development. Mothers generally don’t smoke and drink during pregnancy any longer, for example, and these factors influence the resulting size of the baby. That however would only explain a small growth, rather than why babies are increasingly being born LGA.

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Can The Cold Be Good For You?
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

Can The Cold Be Good For You?

Despite romantic ideas of long walks in the snow or being curled up by a roaring fire with a good book, being cold is rarely fun. It can be bad for you too, as statistics show that cold weather is 20 times more likely to kill you than hot weather[1]. It’s no wonder, then, that so many of us crave the summertime when the weather is warm and people seem instinctively happier. Nevertheless, there is a growing group of people who believe that, despite the dangers, braving the cold can actually be very good for you.

Do You Dare?

Dutch dare-devil Wim Hof is one of these people and is, in fact, the founder of a whole school of thought when it comes to the cold. Nicknamed ‘The Iceman’, it seems that Hof has always had an affinity to the cold weather. Even in his teenage years, he was running barefoot in the snow. Since then, he has broken no less than 21 world records in relation to the cold, including the record for the longest time spent immersed in an ice-bath, running a marathon above the Arctic Circle wearing only sandals and shorts, and unofficially, swimming under ice for a huge 120 meters having taken only one breath[2]. Rather impressive, undoubtedly, but Hof claims that through all his experiences, he has developed a technique that control his own autonomic nervous system – something that science has, up until recently, said simply cannot be done[3].

 

 

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DNA Fitness Tests: Are They Worth It?
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

DNA Fitness Tests: Are They Worth It?

Genetics is amazing. It tells us so much about humanity and it’s a minefield of information. Admittedly, it’s a minefield that has only just been touched upon, but scientists argue that genetics is the answer to everything – so does that include diet and fitness? Companies like DNAFit say yes. They argue that the results of a DNA test will allow you to develop a personal gene-based diet and fitness plan that works for you – and that brings a whole new meaning to the term ‘tailor-made’. It may sound like a futuristic way to develop a fitness plan, and the possibilities are nothing if not intriguing, but there are some questions of the efficacy of these tests. So can they really help you improve your diet and fitness? And are they worth the money?

What They Do

At a very basic level, our genes dictate everything. Like a computer code written into us before we’re even born, our genes influence everything we do in life and how we respond to different external stimuli – and that, of course, includes how we respond to different foods and exercises. It makes sense, then, that a DNA test could tell us what foods are best for us to eat and which exercises will have the best results. Companies like DNAFit are now branching out from working with only professional athletes to providing home-testing kits and the results can provide information about your sensitivity to carbohydrates, salt, saturated fats, lactose, and gluten. You can find out about your specific requirements when it comes to anti-oxidants and vitamins, and your ability to process things like caffeine and alcohol. Not only that, but you can discover which sports suit you best – endurance sports or power sports? These tests even claim to tell you how likely you are to injure yourself during training and how long it will take you to recover[1].

 

 

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Designer Babies: Is Gene Selection Ever Acceptable?
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

Designer Babies: Is Gene Selection Ever Acceptable?

The term ‘designer babies’ has been bandied around for some years now, and refers to babies whose genetic make-up has been selected or altered. This could be to eradicate a disease or defect, or it could be to ensure that particular genes are present. The idea has been discussed in science for many years and in science fiction, the concept has been around for much, much longer. The issue, however, is extremely controversial and as science races to meet science-fiction, the debate is becoming a serious one.  

Pre-Implantation Genetic Diagnosis

Actually, the concept of ‘designer babies’ is not that far-fetched and already, doctors and scientists use some form of gene-selection during in-vitro fertilization (IVF) treatments. Pre-implantation genetic diagnosis, or PGD, refers to the practice of screening IVF embryos both for disease and for gender selection. Using this process, scientists can remove the defective mitochondria (the ‘powerhouse’ of cells) from an embryo and replace it with healthy mitochondria from a donor egg, and in this way they can effectively ‘design’ babies without certain diseases. Of course, the process doesn’t work for all diseases, and they can actually use this process for non-medical preferences too, such as the gender of the resulting child. Both forms of PGD are currently legal in the US, although the American Congress of Obstetricians and Gynecologists frowns upon the latter use, arguing that by allowing parents to choose the gender of their child, we run the risk of increasing sex discrimination[1].

DNA Editing

There is more to come though. Dr. Tony Perry of the University of Bath in the UK was one of the first scientists to clone mice and pigs, and he claims that more in-depth DNA editing is on its way. It won’t be long, he says, until we can pick and choose which parts of our baby’s DNA that we want to cut out and potentially replace with new pieces of gene-code[2]. In fact, it’s already begun. Earlier this year, scientists in China took discarded IVF embryos and began experiments to correct the abnormal gene that causes the blood disorder beta thalassemia[3]. Even though these embryos were due to be destroyed, the experiments incited much controversy. Whilst few would argue against potential disease eradication, this technique could be used to alter healthy genes too and the real question is how far would be too far?

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The Benefits of a Good Scare
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

The Benefits of a Good Scare

It is around this time of year that scaring becomes a big deal. Houses are strung with Halloween decorations from spiders to ghosts and ghouls, and then often splashed with ‘blood’ as well. Families and friends play tricks on each other or gather together in dark rooms to watch scary movies or tell terrifying tales. Haunted houses make a killing too – if you’ll excuse the pun! Of course, it’s not just in October that we liked to be scared either. In fact, all year round, people partake in extreme sports or adrenaline pumping activities and the scare industry is big business. We make an event of being scared, eagerly anticipating it and taking a thrill from it afterwards. In short: we love it!

What’s odd about this is that should any of these activities have a genuine, real-life affect, we’d be terrified – and not in a good way, as intended. Most people would not want to be put into a genuinely life threatening situation and fear is our brain’s way of protecting us from that. It warns us of a threat and helps us to react accordingly, but when it comes to thrill seeking, a lot of people thrive on a good scare. So we know that some people enjoy it. The question is, though, can a scare actually be good for you?

The answer? Absolutely it can, and this is why:

 The High

The first and perhaps most obvious benefit of being scared is the natural high that comes with it. When faced with a potentially threatening situation, our bodies go into what is known as the fight or flight response. At its base, this is a release of adrenaline that allows us to either flee from the situation or act quickly and efficiently to fight it. At a more complex level, it’s a physiological change. Our heart rate increases, our breath quickens, we begin to sweat, our muscle tense, and our concentration focuses narrowly on the perceived threat. Our brains are also flooded with chemicals such as dopamine and endorphins – yes, the same ones that give you a buzz after exercising[1].

It’s not fight or flight that is, in itself, enjoyable. In a genuinely threatening situation, we wouldn’t get a buzz from this response, but rather would be able to react in a way that better suited the circumstances. Dr. Margee Kerr, a scare specialist at Robert Morris University says the response becomes enjoyable when we know that we are away from harm. Once we accept that we are safe, we are free to enjoy the chemical rush and enjoy that sense of relief – or even of achievement – that we feel once we get through a haunted house or scary movie[2].

 

 

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Modafinil and Neuro-enhancement: Delightful or Dangerous?
Health & Homeostasis Victoria Froud, MA Health & Homeostasis Victoria Froud, MA

Modafinil and Neuro-enhancement: Delightful or Dangerous?

What Is It?

Science fiction is abound with neuro-enhancement technologies and medications.  The Bradley Cooper film Limitless is just one example, in which characters discover a street drug that allows them to unleash 100% of their brain power, becoming not just more productive but more charming, cleaner, and more energetic.  But could such a drug ever exist?  Perhaps.  Whilst not on the same level as the drug in Limitless, Modafinil is tipped to be the first true neuro-enhancement drug suitable for healthy people. 

The FDA approved drug, which is marketed as Provigil in the US and the UK is a schedule IV drug, meaning that you must have a doctor’s prescription in order to legally buy it or possess it[1], although there are plenty of off-label versions of the drug being sold on illegal, overseas websites.  At its base, it’s a stimulant that is prescribed to people suffering from sleep disorders such as narcolepsy and is used to increase the cognitive functions of people with neuropsychiatric disorders and shift-work related sleep deprivation[2].  It has later become a nootropic, or ‘smart drug’, taken by healthy people to increase concentration, memory, alertness, energy, and motor skill as well as reducing sleepiness[3]

Doctor Peter Morgan from Yale University explains that it is effective because it acts on several different neurotransmitters at once.  It affects your dopamine levels, making you more alert and more interested in things.  It affects your norepinephrine, again improving alertness and focus.  It affects histamine too, which keeps you awake.  It is also believed to enhance short-term memory by as much as ten per cent by influencing the neurotransmitter glutamate[4].  It could affect other transmitters too, meaning that the reaction is different for different people. 

That’s a lot of cognitive improvement from one little pill, and the list of people taking it is impressive.  It’s prescribed to surgeons who need the boost to get them through long surgical procedures whilst maintaining a steady hand.  It’s prescribed to long-haul airline pilots and shift workers.  There are also many famous people who reportedly take it to help with day-to-day living.  Tim Ferriss, author of The 4-Hour Workweek is one, comedian and actor Joe Rogan is another.  Even President Obama is rumored to have taken it[5].  For those not so famous, the internet is littered with case studies and personal proclamations regarding the greatness of this drug and its potential for the future of neuro-enhancement.  All this though, makes it easy to wonder: is it just too good to be true?

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Does Modern Life Cause Early-Onset Dementia?
Health & Homeostasis, Mental Health, Women's Health Victoria Froud, MA Health & Homeostasis, Mental Health, Women's Health Victoria Froud, MA

Does Modern Life Cause Early-Onset Dementia?

     Dementia affects millions of people worldwide and in the US, there are presently an estimated five million people suffering from age-related dementia.  If you are in America and you are over the age of 85, you have a one in two chance of developing some sort of dementia[1].  It is the sixth leading cause of death[2].  In 2015, nearly one in five Medicare dollars will be spent on dementia and Alzheimer’s will cost $226 billion.  By 2050, that cost is expected to rise to $1.1 trillion[3].  It’s a terrifying fact. 

     Dementia is an umbrella term for disorders of mental processes caused by brain diseases or injury.  There are a number of different types of dementia but by far the most prevalent and most well-known is Alzheimer’s, which currently accounts for around 70% of all dementia diagnoses[4].  What’s worrying is that dementia diagnoses are increasing as the population ages, as are deaths from neurological diseases like Alzheimer’s.  What’s more worrying, though, is that dementia is affecting individuals at a younger and younger age. 

 Dementia and the Youth of Today

     Whilst previously, ‘early-onset dementia’ referred to people in their mid to late 60s, it is now starting to refer to people diagnosed as young as 30 and 40.  That’s a frightening concept, and whilst some claim that it’s the result of living longer and being better at curing other diseases (because, they claim, everybody has to die of something), Colin Pritchard of Bournemouth University in the UK is not so sure.  Pritchard and his team of researchers examined the mortality data from the World Health Organization and looked at the changing pattern of neurological deaths across 21 western countries, from as far back as 1979[5].  What they discovered was startling. 

 

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